Avoid contact sports or activities with a high risk of head injury. Your doctor might prescribe a shorter acting blood thinner (heparin) while you're not taking warfarin. You might need to decrease or stop your warfarin dose at least five days before surgery. Share this information even before minor procedures, such as vaccinations and routine dental cleanings.

Tell care providers that you take warfarin before you have medical or dental procedures.

Ask if you need testing to see if a new medication affects your warfarin treatment.

Tell your health care provider about all medications, herbal remedies or supplements you take.

To reduce the risk of a bleeding event from warfarin treatment, follow these guidelines: Perioperative Management of Direct Oral Anticoagulants (DOACs): A Systemic Review. Sunkara T, Ofori E, Zarubin V, Caughey ME, Gaduputi V, Reddy M. Perioperative Management of Antithrombotic Therapy. | Open in Read by QxMDĭouketis JD, Spyropoulos AC, Spencer FA, et al. The reversal of anticoagulation in clinical practice . Activated prothrombin complex concentrates for the reversal of anticoagulant-associated coagulopathy.

| Open in Read by QxMDĢ011 Clinical Practice Guide on Anticoagulant Dosing and Management of Anticoagulant Associated Bleeding Complications in Adults.Īwad NI, Cocchio C.

Assessing bleeding risk in patients taking anticoagulants. Guideline for Reversal of Antithrombotics in Intracranial Hemorrhage. | Open in Read by QxMDįrontera JA, Lewin III JJ, Rabinstein AA, et al. How to effectively manage the event of bleeding complications when using anticoagulants. Nonspecific reversal agents like 4-factor prothrombin complex concentrate ( PCC), activated PCC, recombinant activated factor VII, thrombocyte concentrates, and fresh frozen plasma have procoagulatory effects! Before these drugs are administered, the increased risk of thrombosis should be carefully weighed against the risk of ongoing bleeding. Andexanet alfa (inactive, recombinant factor Xa).

Rivaroxaban: 5–9 hours ( 11–13 hours in elderly).

Idarucizumab ( monoclonal antibody Fab fragments).

Activated prothrombin complex concentrate ( aPCC).

Synthetic pentasaccharide factor Xa inhibitors

4-factor prothrombin complex concentrate ( PCC rapid reversal).

Antidote of warfarin overdose